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An accurate and dual-effective body slimming method through a soluble microneedle patch with variable temperature

Abstract

Obesity is a chronic and recurrent disease with potential risks. Traditional weight-loss methods (like exercises, surgeries or oral drugs, etc.) have shown different side effects. In this experiment, the microneedle (MN) patch was selected as the drug carrier of the weight-loss drug Rosiglitazone (Rosi). Besides, melanin was added to enhance the photo-thermal effect and accelerate the release of drugs to the target fat region under near-infrared (NIR) light. Afterwards, with exterior cold stimulation, the significant and accurate effect of body slimming could be achieved. This combination of soluble MN patches and variable temperatures provides an attractive nonsurgical method for future accurate body slimming management.

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Supplementary files

Article information


Submitted
22 Jun 2020
Accepted
06 Oct 2020
First published
07 Oct 2020

J. Mater. Chem. B, 2020, Accepted Manuscript
Article type
Paper

An accurate and dual-effective body slimming method through a soluble microneedle patch with variable temperature

H. Peng, Y. Zhou, C. Zhang, M. Wang, S. Zhao, Y. Xu, W. Zhang, H. Xin and X. Wang, J. Mater. Chem. B, 2020, Accepted Manuscript , DOI: 10.1039/D0TB01547D

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