Issue 44, 2020

Reversible antibiotic loading and pH-responsive release from polymer brushes on contact lenses for therapy and prevention of corneal infections

Abstract

Corneal infection is an important cause of corneal damage and vision loss. In this work, polyhydroxy antibiotics were grafted onto polymer brush-modified contact lenses through dynamic chemical bonds between polyphenolic hydroxyls and phenylboronic acid. Both in vitro and in vivo antibacterial tests demonstrated great promise in the prevention of bacterial keratitis, which could be attributed to the enhanced retention time and drug bioavailability.

Graphical abstract: Reversible antibiotic loading and pH-responsive release from polymer brushes on contact lenses for therapy and prevention of corneal infections

Supplementary files

Article information

Article type
Communication
Submitted
17 Jun 2020
Accepted
14 Aug 2020
First published
20 Aug 2020

J. Mater. Chem. B, 2020,8, 10087-10092

Reversible antibiotic loading and pH-responsive release from polymer brushes on contact lenses for therapy and prevention of corneal infections

Y. Guo, S. Qian, L. Wang, J. Zeng, R. Miao, Y. Meng, Y. Jin, H. Chen and B. Wang, J. Mater. Chem. B, 2020, 8, 10087 DOI: 10.1039/D0TB01508C

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