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Reversible antibiotic loading and pH-responsive release from polymer brushes on contact lenses for therapy and prevention of corneal infections

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Abstract

Corneal infection is an important cause of corneal damage and vision loss. In this work, polyhydroxy antibiotics were grafted onto polymer brush-modified contact lenses through dynamic chemical bonds between polyphenolic hydroxyls and phenylboronic acid. Both in vitro and in vivo antibacterial tests demonstrated great promise in the prevention of bacterial keratitis, which could be attributed to the enhanced retention time and drug bioavailability.

Graphical abstract: Reversible antibiotic loading and pH-responsive release from polymer brushes on contact lenses for therapy and prevention of corneal infections

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Article information


Submitted
17 Jun 2020
Accepted
14 Aug 2020
First published
20 Aug 2020

J. Mater. Chem. B, 2020, Advance Article
Article type
Communication

Reversible antibiotic loading and pH-responsive release from polymer brushes on contact lenses for therapy and prevention of corneal infections

Y. Guo, S. Qian, L. Wang, J. Zeng, R. Miao, Y. Meng, Y. Jin, H. Chen and B. Wang, J. Mater. Chem. B, 2020, Advance Article , DOI: 10.1039/D0TB01508C

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