Issue 33, 2020

Aggregation-induced fluorescence probe for hypochlorite imaging in mitochondria of living cells and zebrafish

Abstract

Hypochlorite is an important active oxygen species formed in living organisms, and rapid and highly sensitive detection of trace hypochlorite is of great significance for understanding the mechanism of diseases caused by abnormal hypochlorite concentrations at an early stage. Although aggregation-induced emission (AIE) probes are highly important for analyte de-tection in living organisms, there is a lack of AIE probes for hypochlorite detection. In this study, two AIE probes based on benzothiazole derivatives (BTD-1 and BTD-2) were designed and synthesized. Both probes exhibited good AIE charac-teristics and allowed different visual detection for hypochlorite. Additionally, the two probes could be used to detect endogenous hypochlorite in mitochondria and were successfully applied for in vivo hypochlorite imaging in zebrafish.

Graphical abstract: Aggregation-induced fluorescence probe for hypochlorite imaging in mitochondria of living cells and zebrafish

Supplementary files

Article information

Article type
Paper
Submitted
15 Jun 2020
Accepted
06 Jul 2020
First published
06 Jul 2020

J. Mater. Chem. B, 2020,8, 7375-7381

Aggregation-induced fluorescence probe for hypochlorite imaging in mitochondria of living cells and zebrafish

X. Zhong, Q. Yang, Y. Chen, Y. Jiang and Z. Dai, J. Mater. Chem. B, 2020, 8, 7375 DOI: 10.1039/D0TB01496F

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