Jump to main content
Jump to site search

Issue 38, 2020
Previous Article Next Article

ROS-initiated chemiluminescence-driven payload release from macrocycle-based Azo-containing polymer nanocapsules

Author affiliations

Abstract

Reactive oxygen species (ROS) overproduction is involved in many pathological processes, particularly in inflammatory diseases. Therefore, ROS-responsive nanocarriers for specific drug release have been highly sought after. Herein we developed a ROS-responsive drug delivery system based on covalently self-assembled polymer nanocapsules (Azo-NCs) formed via crosslinking macrocyclic cucurbit[6]urils by a photo-sensitive azobenzene derivative (Azo). Luminol, a chemiluminescent molecule activatable by ROS, was co-loaded into Azo-NCs together with a therapeutic payload. When exposed to high ROS concentration that is typically encountered in inflammatory cells or tissues, the ROS-initiated blue chemiluminescence of luminol drives photoisomerization of the Azo groups within Azo-NCs, leading to Azo-NCs’ surface transformation and distortion of the nanostructure, and subsequent payload release. As a proof-of-concept, ROS-responsive payload release from luminol-loaded Azo-NCs in inflammatory cells and zebrafish was demonstrated, showing promising anti-inflammatory effects in vitro and in vivo.

Graphical abstract: ROS-initiated chemiluminescence-driven payload release from macrocycle-based Azo-containing polymer nanocapsules

Back to tab navigation

Supplementary files

Article information


Submitted
12 Jun 2020
Accepted
13 Aug 2020
First published
13 Aug 2020

J. Mater. Chem. B, 2020,8, 8878-8883
Article type
Paper

ROS-initiated chemiluminescence-driven payload release from macrocycle-based Azo-containing polymer nanocapsules

C. Sun, Z. Wang, L. Yue, Q. Huang, S. Lu and R. Wang, J. Mater. Chem. B, 2020, 8, 8878
DOI: 10.1039/D0TB01475C

Social activity

Search articles by author

Spotlight

Advertisements