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A minireview of viscosity-sensitive fluorescent probes: design and biological applications

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Abstract

Microenvironment-related parameters like viscosity, polarity, and pH play important roles in controlling the physical or chemical behaviors of local molecules, which determine the physical or chemical behaviors of surrounding molecules. In general, changes of the internal microenvironment will usually lead to cellular malfunction or the occurrence of relevant diseases. In the last few decades, the field of chemicobiology has received great attention. Also, remarkable progress has been made in developing viscosity-sensitive fluorescent probes. These probes were particularly efficient for imaging viscosity in biomembranes as well as lighting up specific organelles, such as mitochondria and lysosome. Besides, there are some fluorescent probes that can be used to quantify intracellular viscosity when combined with fluorescence lifetime (FLIM) and ratiometric imaging under water-free conditions. In this review, we summarized the majority of viscosity-sensitive chemosensors that have been reported thus far.

Graphical abstract: A minireview of viscosity-sensitive fluorescent probes: design and biological applications

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Article information


Submitted
03 May 2020
Accepted
19 Jul 2020
First published
02 Sep 2020

J. Mater. Chem. B, 2020, Advance Article
Article type
Review Article

A minireview of viscosity-sensitive fluorescent probes: design and biological applications

C. Ma, W. Sun, L. Xu, Y. Qian, J. Dai, G. Zhong, Y. Hou, J. Liu and B. Shen, J. Mater. Chem. B, 2020, Advance Article , DOI: 10.1039/D0TB01146K

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