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Recent advances in MoS2-based photothermal therapy for cancer and infectious disease treatment

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Abstract

Photothermal therapy (PTT) is a treatment combining laser irradiation and a photothermal transduction agent (PTA) to generate hyperthermia, which is used to efficiently and effectively treat cancer and prevent bacteria-induced infectious diseases. MoS2, an increasingly used two-dimensional transition metal dichalcogenide, which shows high absorbance in the near infrared (NIR) laser region, has been extensively utilized as a novel PTA in biomedical applications. The use of MoS2 as an advanced photoabsorbing agent has introduced a more efficient cancer therapy and improved antibacterial efficacy. In this review, we firstly summarize the recent advances in the MoS2-based platform for PTT in cancer and bacteria-induced infectious diseases treatments. We then discuss that the combination of MoS2-based PTT and other biomedical methods along with multimodality imaging, such as chemotherapy, photodynamic therapy (PDT) and immunotherapy, might be a promising strategy for cancer treatment. Furthermore, a new concept is proposed wherein MoS2-based PTT and combined therapies based on this could be more effective for the treatment of various bacteria-induced infectious diseases. Finally, research progress, challenges, and perspectives for the future development of this MoS2-based platform in cancer and bacteria-induced infectious disease treatments are discussed and concluded. Collectively, we think that MoS2-based PTT with high therapeutic efficacy and minimal side-effects could be potentially applied in clinical settings to improve cancer and infectious disease treatments.

Graphical abstract: Recent advances in MoS2-based photothermal therapy for cancer and infectious disease treatment

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Article information


Submitted
19 Apr 2020
Accepted
05 Jun 2020
First published
05 Jun 2020

J. Mater. Chem. B, 2020, Advance Article
Article type
Review Article

Recent advances in MoS2-based photothermal therapy for cancer and infectious disease treatment

J. Shi, J. Li, Y. Wang, J. Cheng and C. Y. Zhang, J. Mater. Chem. B, 2020, Advance Article , DOI: 10.1039/D0TB01018A

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