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Issue 26, 2020
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Controllable synthesis of biomimetic nano/submicro-fibrous tubes for potential small-diameter vascular grafts

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Abstract

Mimicking the morphological structure of native blood vessels is critical for the development of vascular grafts. Herein, small-diameter composite vascular grafts that integrate the nanofibrous bacterial cellulose (BC) and submicrofibrous cellulose acetate (CA) were fabricated via a combined electrospinning and step-by-step in situ biosynthesis. Scanning electron microscopy (SEM) observation shows the nano/submicro-fibrous morphology and well-interconnected porous structure of the BC/CA grafts. It is found that the BC/CA graft with a suitable BC content demonstrates lower potential of thrombus formation and enhanced endothelialization as compared to the BC and CA counterparts. Western blotting and RT-qPCR results suggest that the BC/CA-2 graft promotes endothelialization by improving expressions of genes vWF-1 and CD31 and protein CD31. The in vivo tests demonstrate much lower inflammatory response to the BC/CA graft. These results suggest that the BC/CA graft shows a great potential as an artificial graft for rapid formation of an endothelial cell monolayer.

Graphical abstract: Controllable synthesis of biomimetic nano/submicro-fibrous tubes for potential small-diameter vascular grafts

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Article information


Submitted
17 Apr 2020
Accepted
31 May 2020
First published
03 Jun 2020

J. Mater. Chem. B, 2020,8, 5694-5706
Article type
Paper

Controllable synthesis of biomimetic nano/submicro-fibrous tubes for potential small-diameter vascular grafts

Y. Wan, S. Yang, M. Peng, M. Gama, Z. Yang, X. Deng, J. Zhou, C. Ouyang and H. Luo, J. Mater. Chem. B, 2020, 8, 5694
DOI: 10.1039/D0TB01002B

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