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Mechanically adaptive implants fabricated with poly(2-hydroxyethyl methacrylate)-based negative photoresists

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Abstract

Neural implants that are based on mechanically adaptive polymers (MAPs) and soften upon insertion into the body have previously been demonstrated to elicit a reduced chronic tissue response than more rigid devices fabricated from silicon or metals, but their processability has been limited. Here we report a negative photoresist approach towards physiologically responsive MAPs. We exploited this framework to create cross-linked terpolymers of 2-hydroxyethyl methacrylate, 2-hydroxyethyl acrylate and 2-ethylhexyl methacrylate by photolithographic processes. Our systematic investigation of this platform afforded an optimized composition that exhibits a storage modulus E′ of 1.8 GPa in the dry state. Upon exposure to simulated physiological conditions the material swells slightly (21% w/w) leading to a reduction of E′ to 2 MPa. The large modulus change is mainly caused by plasticization, which shifts the glass transition from above to below 37 °C. Single shank probes fabricated by photolithography could readily be implanted into a brain-mimicking gel without buckling and viability studies with microglial cells show that the materials display excellent biocompatibility.

Graphical abstract: Mechanically adaptive implants fabricated with poly(2-hydroxyethyl methacrylate)-based negative photoresists

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Supplementary files

Article information


Submitted
15 Apr 2020
Accepted
08 Jun 2020
First published
08 Jun 2020

This article is Open Access

J. Mater. Chem. B, 2020, Advance Article
Article type
Paper

Mechanically adaptive implants fabricated with poly(2-hydroxyethyl methacrylate)-based negative photoresists

B. Monney, A. E. Hess-Dunning, P. Gloth, J. R. Capadona and C. Weder, J. Mater. Chem. B, 2020, Advance Article , DOI: 10.1039/D0TB00980F

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    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
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