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Research status and development potential of composite hemostatic materials

Abstract

Bleeding is a serious accident that happens in people’s daily life or clinical.Bleeding can be caused by accidental trauma, surgery, congenital disease, or blood disorders caused by drugs. Excessive bleeding in the body can lead to illness or death. Adequate hemostasis is an essential way of preventing bleeding from avoiding death and is the first step in wound healing. With the rapid development of science and technology, various hemostatic materials have been developed in the hope of enhancing the hemostatic effect by activating different coagulation mechanisms. Such as the formation of physical barriers, aggregation of platelets, the concentration of blood components, and the release of clotting factors. The creation of composite hemostatic materials meets the requirement that multiple coagulation mechanisms can be activated simultaneously to enhance the hemostatic effect. Combined with the research status of composite hemostatic materials, it is found that there is still a lack of a highly biocompatible, variable shape, can be used for internal and external bleeding at the same time, can be degraded in vivo, camouflage platelets or red blood cells and other clotting related factors hemostasis. Therefore, the future development potential and optimization direction of composite hemostatic materials were proposed through an in-depth discussion of their characteristics and coagulation mechanism. It is hoped to provide a reference for the researchers of hemostatic materials.

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Article information


Submitted
06 Apr 2020
Accepted
17 May 2020
First published
19 May 2020

J. Mater. Chem. B, 2020, Accepted Manuscript
Article type
Review Article

Research status and development potential of composite hemostatic materials

C. Zheng, Q. Zeng, S. Pimpi, W. Wu, K. Han, K. Dong and T. Lu, J. Mater. Chem. B, 2020, Accepted Manuscript , DOI: 10.1039/D0TB00906G

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