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Artificial protein-probe hybrid as a responsive probe for ratiometric detection and imaging of hydrogen peroxide in cells

Abstract

A novel fluorescent protein-probe hybrid, Cm-Np-B@BSA, was prepared through host-guest interactions between hydrogen peroxide (H2O2)-responsive Cm-Np-B molecule and bovine serum albumin (BSA). Cm-Np-B@BSA hybrid probe exhibited high sensitivity and selectivity towards H2O2 under physiological conditions with excellent biocompatibility, allowing for sensitive ratiometric detection and imaging of endogenous H2O2 in living cells.

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Supplementary files

Article information


Submitted
01 Apr 2020
Accepted
21 May 2020
First published
21 May 2020

J. Mater. Chem. B, 2020, Accepted Manuscript
Article type
Communication

Artificial protein-probe hybrid as a responsive probe for ratiometric detection and imaging of hydrogen peroxide in cells

X. Zhang, Y. Fu, G. Qian, R. Zhang and Z. P. Xu, J. Mater. Chem. B, 2020, Accepted Manuscript , DOI: 10.1039/D0TB00856G

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