Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.



Self-recognizing and stimulus-responsive carrier-free metal-coordinated nanotheranostics for magnetic resonance/photoacoustic/fluorescence imaging-guided synergistic photo-chemotherapy

Abstract

Carrier-free nanotheranostics directly assembled by clinically used photosensitizers and chemotherapeutic drugs are a promising alternative for tumor theranostic. However, the weak interaction-driven assembly still suffers from low structural stability against disintegration, lack of targeting specificity, and poor stimulus-responsive property. Moreover, almost all exogenous ligands possess no therapeutic effect. Enlightened by the concept of metal-organic frameworks, we developed a novel self-recognizing metal-coordinated nanotheranostic agent by coordination-driven co-assembly of photosensitizer indocyanine green (ICG) and chemo-drug methotrexate (MTX, also served as a specific “targeting ligand” towards folate receptors), in which ferric (FeⅢ) ion acted as a bridge to tightly associate ICG with MTX. Such carrier-free metal-coordinated nanotheranostics with high dual-drug payload (~94 wt%) not only possessed excellent structural and physiological stability, but also exhibited prolonged blood circulation. Additionally, the nanotheranostics could achieve targeted on-demand drug release by both stimuli of internal lysosomal acidity and external near-infrared laser. More importantly, the nanotheranostics could self-recognize the cancer cells and selectively target to the tumors, therefore it decreased toxicity to normal tissues and organs. Consequently, the nanotheranostics showed strongly synergistic potency for tumor photo-chemotherapy under the precise guidance of magnetic resonance/photoacoustic/fluorescence imaging, thereby achieving highly effective tumor cure efficiency. Considering that ICG and bi-functional MTX are approved by Food and Drug Administration, and FeⅢ ions have high biosafety, the self-recognizing and stimulus-responsive carrier-free metal-coordinated nanotheranostics may hold potential application in tumor theranostic.

Back to tab navigation

Supplementary files

Article information


Submitted
31 Mar 2020
Accepted
09 May 2020
First published
11 May 2020

J. Mater. Chem. B, 2020, Accepted Manuscript
Article type
Paper

Self-recognizing and stimulus-responsive carrier-free metal-coordinated nanotheranostics for magnetic resonance/photoacoustic/fluorescence imaging-guided synergistic photo-chemotherapy

L. Tu, Z. Fan, F. Zhu, Q. Zhang, S. Zeng, Z. Chen, L. Ren, Z. Hou, S. Ye and Y. Li, J. Mater. Chem. B, 2020, Accepted Manuscript , DOI: 10.1039/D0TB00850H

Social activity

Search articles by author

Spotlight

Advertisements