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Affinity purification of multifunctional oligomeric ligands synthesized via controlled radical polymerization

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Abstract

Abiotic oligomeric ligands with a strong affinity for a target peptide sequence were isolated by affinity purification from a pool of 30-mer acrylic random ter-oligomers that were synthesized via a controlled radical polymerization process. Our results indicate that the oligomeric ligands with suitable sequence and/or stereochemical configurations for the target can be isolated from as-polymerized random co-polymers based on the affinity to the target. This process will be a powerful tool for the development of stable and inexpensive ligands that can be used to detect, neutralize and purify proteins with a target epitope sequence.

Graphical abstract: Affinity purification of multifunctional oligomeric ligands synthesized via controlled radical polymerization

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Supplementary files

Article information


Submitted
31 Mar 2020
Accepted
26 May 2020
First published
26 May 2020

J. Mater. Chem. B, 2020, Advance Article
Article type
Communication

Affinity purification of multifunctional oligomeric ligands synthesized via controlled radical polymerization

Y. Hoshino, S. Shimohara, Y. Wada, M. Nakamoto and Y. Miura, J. Mater. Chem. B, 2020, Advance Article , DOI: 10.1039/D0TB00849D

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