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Progress on therapeutic applications of polymer decorated black phosphorus and black phosphorus analogues nanomaterials in biomedicine

Abstract

Wonder black phosphorus (BP) and some BP-analogue materials (BPAs) shown remarkable potential for biomedical applications owing to their excellent chemical, physical, optical and electronic properties, but opportunities and challenges always coexist throughout the study. Poor stability upon exposure to natural environment is the major obstacle hampering their application in vivo. Polymer can not only efficiently prevent their oxidation and aggregation but also exhibit “biological activity” due to the synergistic effects. In this review, we briefly described the synthesis methods and stability strategies of BP/polymer and BPAs/polymer. Then, advances pertaining of their exciting therapeutics applications in various fields are emphatically introduced, including cancer therapy (phototherapy, drug delivery, synergistic immunotherapy), bone regeneration, neurogenesis. Some challenges for future clinic and possible directions on further study are discussed at the end of paper.

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Article information


Submitted
28 Mar 2020
Accepted
09 Jun 2020
First published
12 Jun 2020

J. Mater. Chem. B, 2020, Accepted Manuscript
Article type
Review Article

Progress on therapeutic applications of polymer decorated black phosphorus and black phosphorus analogues nanomaterials in biomedicine

D. An, J. Fu, M. Qiu and H. Zhang, J. Mater. Chem. B, 2020, Accepted Manuscript , DOI: 10.1039/D0TB00824A

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