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Biodegradable phosphorylcholine copolymer for cardiovascular stent coating

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Abstract

Phosphorylcholine (PC) based polymer coatings with excellent biocompatibility have shown successful commercialization in drug-eluting stents. However, poor degradability represents a challenge in the application of biodegradable stents. Herein, a biodegradable phosphorylcholine copolymer is developed based on one-step radical ring-opening polymerization (RROP). This copolymer was synthesized by copolymerization of a PC unit, degradable ester (2-methylene-1,3-dioxepane, MDO) unit and non-degradable butyl methacrylate (BMA) unit, which showed ratio controllability by changing the monomer ratio during polymerization. We demonstrated that the copolymer with the ratio of 34% MDO, 19% MPC and 47% BMA could form a stable coating by ultrasonic spray, and showed good blood compatibility, anti-adhesion properties, biodegradability, and rapamycin eluting capacity. In vivo study revealed its promising application as a biodegradable stent coating. This work provides a facile path to add biodegradability into PC based polymers for further bio-applications.

Graphical abstract: Biodegradable phosphorylcholine copolymer for cardiovascular stent coating

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Supplementary files

Article information


Submitted
27 Mar 2020
Accepted
15 May 2020
First published
18 May 2020

J. Mater. Chem. B, 2020, Advance Article
Article type
Paper

Biodegradable phosphorylcholine copolymer for cardiovascular stent coating

J. Liu, J. Wang, Y. Xue, T. Chen, D. Huang, Y. Wang, K. Ren, Y. Wang, G. Fu and J. Ji, J. Mater. Chem. B, 2020, Advance Article , DOI: 10.1039/D0TB00813C

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