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Programmable Assembly of Gold Nanoparticle Nanoclusters and Lattices


Deterministic assembly of metallic nanoparticles (e.g. gold nanoparticles) into prescribed configurations have promising applications in many fields such as biosensing and drug delivery. DNA-directed bottom-up assembly has demonstrated unparalleled capability to precisely organize metallic nanoparticles into assemblies of designer configurations. However, the fabrication of assemblies comprising delicate nanoparticle arrangements, especially across large dimensions (e.g. micron size), has remained challenging. In this report, we have designed DNA origami hexagon tiles that are capable of assembling into higher-order networks of honeycomb arrays or tubes with dimensions up to several microns. The versatile addressability of the unit tile enables precise and periodic positioning of nanoparticles onto these higher-order DNA origami frame structures. Overall, we have constructed a series of 9 gold nanoparticle architectures with programmable configurations ranging from nanometer-sized clusters to micrometer-sized lattices. We believe these architectures shall hold great application potentials in numerous biomedical fields.

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Article information

26 Mar 2020
19 May 2020
First published
19 May 2020

J. Mater. Chem. B, 2020, Accepted Manuscript
Article type

Programmable Assembly of Gold Nanoparticle Nanoclusters and Lattices

L. Shen, V. Pan, H. Li, Y. Zhang, P. Wang and Y. Ke, J. Mater. Chem. B, 2020, Accepted Manuscript , DOI: 10.1039/D0TB00807A

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