Anti-infective Hydrogel Adhesive with Non-swelling and Robust Mechanical Properties for Sutureless Wound Closure
A non-swelling hydrogel adhesive is urgently needed for clinical application of wound closure, however, preparing a non-swelling hydrogel adhesive with superior mechanical and tissue adhesion properties remains a challenge. In this study, we developed a new family of non-swelling hydrogel adhesives composed of Pluronic F127 diacrylate, poly(ethylene glycol) diacrylate, modified sodium alginate, and tannic acid. Hydrogel’s physical and biological properties were systematically evaluated in vitro/vivo. The results indicated that the hydrogels exhibited non-swelling features, robust mechanical properties and good adhesion abilities toward various tissues. The hydrogels also exhibited good cytocompatibility and strong antibacterial activities against S. aureus and E. coli. Additionally, the hydrogel could be used for sutureless wound closure and displayed better advantages compared to suture and commercial adhesive pad. The above results demonstrated that our non-swelling hydrogel adhesive with robust mechanical property hold great promise for the applications in clinical surgery.