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Issue 21, 2020
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A bio-inspired injectable hydrogel as a cell platform for real-time glycaemic regulation

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Abstract

Frequent subcutaneous insulin injection and islet transplantation are promising therapeutic options for type 1 diabetes mellitus. However, poor patient compliance, insufficient appropriate islet β cell donors and body immune rejection limit their clinical applications. The design of a platform capable of encapsulating insulin-secreting cells and achieving real-time blood glucose regulation, is a so far unmet need. Herein, inspired by the natural processes of regulating blood glucose in pancreatic islet β cells, we developed a poly(N-isopropylacrylamide-co-dextran-maleic acid-co-3-acrylamidophenylboronic acid) (P(AAPBA–Dex–NIPAM)) hydrogel as a cell platform with glucose responsiveness and thermo-responsiveness for the therapy of diabetes. This platform showed good biocompatibility against insulin-secreting cells and presented glucose-dependent insulin release behaviour. The bioinspired P(AAPBA6–Dex–NIPAM64) hydrogel had a positive effect on real-time glycaemic regulation, as observed by intraperitoneal glucose tolerance tests. The non-fasting blood glucose of diabetic rats was restored to a normal level during the period of treatment. Additionally, the inflammatory response did not occur after administration of the platform. Collectively, we expected that the bio-mimetic platform combined with an insulin-secreting capability could be a new diabetic treatment strategy.

Graphical abstract: A bio-inspired injectable hydrogel as a cell platform for real-time glycaemic regulation

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Supplementary files

Article information


Submitted
01 Mar 2020
Accepted
20 Apr 2020
First published
22 Apr 2020

J. Mater. Chem. B, 2020,8, 4627-4641
Article type
Paper

A bio-inspired injectable hydrogel as a cell platform for real-time glycaemic regulation

Y. Zhang, J. Yang, J. Zhang, S. Li, L. Zheng, Y. Zhang, H. Meng, X. Zhang and Z. Wu, J. Mater. Chem. B, 2020, 8, 4627
DOI: 10.1039/D0TB00561D

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