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Progress on arginine-based gene delivery systems

Abstract

Gene therapy was deemed to be a powerful and promising tool to treat many of stubborn diseases in the near future. For successful gene therapy, gene vectors played a vital role as it determined whether the edited gene could be loaded and transferred into target cells effectively. However, traditional gene vectors faced some serious challenges, especially in biosafety and trans-membrane efficiency. Recently, inspired by cell-penetrating peptides (CPPs), possessing excellent biosafety and trans-membrane efficiency, various types of arginine-based gene delivery systems were designed and fabricated. In this review, we will briefly exhibit the superiority and mechanism of arginine in promoting membrane penetration. Then, four types of arginine-based gene vectors, including typical liner polymeric, dendrimer, lipids as well as arginine-based composite gene vectors, and their applications will be introduced in detail. Finally, we will point out the current challenge and future perspective of arginine based gene delivery systems.

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Article information


Submitted
23 Feb 2020
Accepted
20 May 2020
First published
22 May 2020

J. Mater. Chem. B, 2020, Accepted Manuscript
Article type
Review Article

Progress on arginine-based gene delivery systems

Y. Zhou, S. Han, Z. Liang, M. Zhao, G. Liu and J. Wu, J. Mater. Chem. B, 2020, Accepted Manuscript , DOI: 10.1039/D0TB00498G

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