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Tumor Microenvironment and NIR Laser Dual Responsive Release of Berberine 9-O-pyrazole Alkyl Derivative Loaded in Graphene Oxide Nanosheets for Chemo-photothermal Synergetic Cancer Therapy

Abstract

Berberine 9-O-pyrazole alkyl derivative, a chemical compound B3 previously synthesized by our group, showed anti-cancer activity. However, B3 lacks targeting cytotoxicity to cancer cells, leading to obvious toxic side effects on normal cells. To solve this problem, here, we prepared a drug delivery system AS1411-GO/B3 for tumor targeting. In which, nano- graphene oxide (GO) sheets were employed as drug carrier, and aptamer AS1411 was conjugated onto GO for tumor targeting. The GO also has photothermal effect, which helps the release of B3 from GO as well as thermal cytotoxicity to cells. We found that the release of B3 could response to the acid condition, indicating the tumor intracellular environment could promote the release of B3, thus to perform the chemotherapy effects. This system could also release B3 in responsive to photothermal heating, moreover combined photothermal therapy and chemotherapy to improve the anticancer activity was achieved. This AS1411-GO/B3 platform with chemo-photothermal synergetic therapy provides a very promising treatment for tumor treatment.

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Supplementary files

Article information


Submitted
22 Feb 2020
Accepted
19 Mar 2020
First published
19 Mar 2020

J. Mater. Chem. B, 2020, Accepted Manuscript
Article type
Paper

Tumor Microenvironment and NIR Laser Dual Responsive Release of Berberine 9-O-pyrazole Alkyl Derivative Loaded in Graphene Oxide Nanosheets for Chemo-photothermal Synergetic Cancer Therapy

P. Du, J. H. Yan, S. Long, H. xiong, N. Wen, S. Cai, Y. Wang, D. Peng, Z. Liu and Y. Liu, J. Mater. Chem. B, 2020, Accepted Manuscript , DOI: 10.1039/D0TB00489H

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