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Silica nanoparticle coated perfluorooctyl bromide for ultrasensitive MRI

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Abstract

MRI with hyperpolarized 129Xe can achieve low-concentration detection. Herein, nanoparticle-coated perfluorooctyl bromide (PFOB) was developed as a 129Xe MRI contrast agent with a moderate exchange rate, sufficient stability and feasible surface modification. The αvβ3 integrin overexpressed by non-small-cell lung cancer A549 cells was successfully detected by 129Xe MRI with high specificity through adequate surface modifications.

Graphical abstract: Silica nanoparticle coated perfluorooctyl bromide for ultrasensitive MRI

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Article information


Submitted
21 Feb 2020
Accepted
07 Apr 2020
First published
07 Apr 2020

J. Mater. Chem. B, 2020, Advance Article
Article type
Communication

Silica nanoparticle coated perfluorooctyl bromide for ultrasensitive MRI

Y. Yuan, Q. Guo, X. Zhang, W. Jiang, C. Ye and X. Zhou, J. Mater. Chem. B, 2020, Advance Article , DOI: 10.1039/D0TB00484G

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