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Issue 26, 2020
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Cell membrane-engineered hybrid soft nanocomposites for biomedical applications

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Abstract

Cell membrane-engineered nanoparticles, integrating the functions of the natural cell membrane and synthetic nanoparticles, are of great interest in various biomedical applications. In particular, cell membrane-engineered hybrid soft nanocomposites (CMHSNCs) with the core of degradable macromolecules or biofunctional molecules, and the shell of various types of functional cell membranes exhibited superior biocompatibility, prolonged circulation and enhanced targeting. They have been explored for cancer therapy, bioimaging, detoxification, anti-virulence and thrombolysis. Herein, recent advances on CMHSNCs are reviewed for delivery of various cargoes including drugs, genes, peptides, proteins, antigens/adjuvants, photoactivatable agents and probes. In addition, the challenges and possible future directions of the CMHSNCs for fundamental research and clinical translation are discussed.

Graphical abstract: Cell membrane-engineered hybrid soft nanocomposites for biomedical applications

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Article information


Submitted
20 Feb 2020
Accepted
04 May 2020
First published
12 May 2020

J. Mater. Chem. B, 2020,8, 5578-5596
Article type
Review Article

Cell membrane-engineered hybrid soft nanocomposites for biomedical applications

Y. Li, Y. Gan, C. Li, Y. Y. Yang, P. Yuan and X. Ding, J. Mater. Chem. B, 2020, 8, 5578
DOI: 10.1039/D0TB00472C

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