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Cell Membrane-Engineered Hybrid Soft Nanocomposites for Biomedical Applications

Abstract

Cell membrane-engineered nanoparticles, integrating the functions of natural cell membrane and synthetic nanoparticles, are of great promise for various biomedical applications. In particular, cell membrane-engineered hybrid soft nanocomposites (CMHSNCs) with the core of degradable macromolecules or biofunctional molecules, and the shell of various types of functional cell membranes exhibited superior biocompatibility, prolonged circulation and enhanced targeting. They have been explored for cancer therapy, bioimaging, detoxification, anti-virulence and thrombolysis. Herein, recent advances on CMHSNCs are reviewed for delivery of various cargoes including drugs, genes, peptides, proteins, adjuvants, photoactivatable agents and probes. In addition, the challenges and future directions of the CMHSNCs for clinical translation are discussed.

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Article information


Submitted
20 Feb 2020
Accepted
04 May 2020
First published
12 May 2020

J. Mater. Chem. B, 2020, Accepted Manuscript
Article type
Review Article

Cell Membrane-Engineered Hybrid Soft Nanocomposites for Biomedical Applications

Y. Li, Y. Gan, C. Li, Y. Y. Yang, P. Yuan and X. Ding, J. Mater. Chem. B, 2020, Accepted Manuscript , DOI: 10.1039/D0TB00472C

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