Biodegradable MnFe-hydroxide Nanocapsules to enable Multi-therapeutics Delivery and Hypoxia-Modulated Tumor Treatment
Developing drug delivery platforms that can modulate tumor microenvironment and deliver multiple therapeutics to targeted tumor is critical for efficient cancer treatment yet remains challenging. Herein, biodegradable nanocapsules based on MnFe hydroxides (H-MnFe(OH)x) have been developed as a new type of delivery cago with high loading capacity and catalytic activity, enabling synergetic therapy with promoted efficacy by relieving hypoxia in tumor tissue. As a proof of concept, a photosensitizer (indocyanine green, ICG) and a chemotherapeutics drug (doxorubicin, DOX) are co-loaded in the nanocapsules and selectively released upon degradation of the nanocapusules in the acidic tumor microenvironment, and promoted by near infrared irradiation. Meanwhile, Mn2+/Fe3+ ions released from the degradation of nanocapsules catalyzes the conversion of H2O2 in tumor microenvironment into oxygen, which modulates tumor hypoxia and dramatically boosts multimodal therapy. Remarkable synergistic anticancer outcomes have been demonstrated both in vitro and in vivo, paving the way towards the future multifunctional theraputic platforms.