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Issue 20, 2020
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Lipid and polymer mediated CRISPR/Cas9 gene editing

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Abstract

A clustered regularly interspaced short palindromic repeats (CRISPR)/associated protein 9 (CRISPR/Cas9) system is the most widely used tool for gene editing. Due to the advantages of simple operation, high efficiency and high specificity, it has been used in various fields. In this review, we introduce the latest research in the delivery technology of CRISPR/Cas9 based on lipids and polymers, which are synthesized through chemical methods. Many successful examples and methods are discussed. In addition, we discuss the potential of these delivery systems used for CRISPR/Cas9 in clinical applications in the future.

Graphical abstract: Lipid and polymer mediated CRISPR/Cas9 gene editing

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Article information


Submitted
22 Jan 2020
Accepted
23 Mar 2020
First published
07 Apr 2020

J. Mater. Chem. B, 2020,8, 4369-4386
Article type
Review Article

Lipid and polymer mediated CRISPR/Cas9 gene editing

Y. Gong, S. Tian, Y. Xuan and S. Zhang, J. Mater. Chem. B, 2020, 8, 4369
DOI: 10.1039/D0TB00207K

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