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Issue 15, 2020
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Magnetic proline-based ionic liquid surfactant as a nano-carrier for hydrophobic drug delivery

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Abstract

Magnetic proline-based surface-active ionic liquid ([ProC10][FeCl3Br]) have been synthesized and investigated for their application in hydrophobic drug delivery. Hydrophobic drugs lead to poor absorptivity, drug aggregation, and high local toxicity. Herein, the vesicular structures formed from [ProC10][FeCl3Br] have been used as drug delivery reactors. The self-assembly behavior of [ProC10][FeCl3Br] in aqueous medium has been investigated using tensiometry, fluorescence, dynamic light scattering (DLS), and transmission electron microscopy (TEM). The physicochemical interactions of [ProC10][FeCl3Br] with animal DNA have been studied using circular dichroism (CD), fluorescence, zeta potential, and gel electrophoresis to confirm its bio-friendly nature. The engendered vesicles prepared from [ProC10][FeCl3Br] have been investigated for the in vitro drug delivery of guest molecule pyrene as a hydrophobic model drug and ciprofloxacin as a hydrophobic antibiotic drug. The drug loading capacity and spontaneous kinetic release of the drug have been studied using various theoretical mathematical drug release models.

Graphical abstract: Magnetic proline-based ionic liquid surfactant as a nano-carrier for hydrophobic drug delivery

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Supplementary files

Article information


Submitted
18 Jan 2020
Accepted
02 Mar 2020
First published
03 Mar 2020

J. Mater. Chem. B, 2020,8, 3050-3057
Article type
Paper

Magnetic proline-based ionic liquid surfactant as a nano-carrier for hydrophobic drug delivery

A. Kulshrestha, P. S. Gehlot and A. Kumar, J. Mater. Chem. B, 2020, 8, 3050
DOI: 10.1039/D0TB00176G

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