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Rational design of water-dispersible and biocompatible nanoprobes with H2S-triggered NIR emission for cancer cell imaging

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Abstract

We present an approach for constructing a H2S-specific nanoprobe by the entrapment of a small molecule probe within the hydrophobic interior of surface cross-linked micelles (SCMs), endowing the designed nanoprobes with good water solubility and biocompatibility. Importantly, the obtained nanoprobes displayed good responsiveness to H2S in both ratiometric fluorescence and light-up NIR emission modes, thus enabling accurate identification of H2S-rich colorectal cancer cells.

Graphical abstract: Rational design of water-dispersible and biocompatible nanoprobes with H2S-triggered NIR emission for cancer cell imaging

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Supplementary files

Article information


Submitted
18 Jan 2020
Accepted
28 Jun 2020
First published
29 Jun 2020

J. Mater. Chem. B, 2020, Advance Article
Article type
Communication

Rational design of water-dispersible and biocompatible nanoprobes with H2S-triggered NIR emission for cancer cell imaging

H. Liu, G. Xu, T. Zhu, R. Wang, J. Tan, C. Zhao and X. Gu, J. Mater. Chem. B, 2020, Advance Article , DOI: 10.1039/D0TB00173B

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