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A novel mitochondria-targeted ratiometric fluorescent probe for endogenous sulfur dioxide derivatives as a cancer-detecting tool

Abstract

A new mitochondria-targeted fluorescence probe RBC, constructed by a coumarin moiety which was selected as the donor and a benzothiazole derivative as the acceptor, for SO2 derivatives (HSO3-/ SO32-) was presented. The probe designed on a new FRET platform showed high selectivity and low detection limit. Importantly, the probe could respond to HSO3-/ SO32- within 35s. Furthermore, the probe could target mitochondria and was successfully used for fluorescence imaging of endogenous bisulfite in HepG2 with low cytotoxicity, which had a significantly assist to cancer diagnosis.

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Supplementary files

Article information


Submitted
16 Jan 2020
Accepted
18 May 2020
First published
18 May 2020

J. Mater. Chem. B, 2020, Accepted Manuscript
Article type
Paper

A novel mitochondria-targeted ratiometric fluorescent probe for endogenous sulfur dioxide derivatives as a cancer-detecting tool

D. Yang, X. He, X. Wu, H. Shi, J. Miao, B. Zhao and Z. lin, J. Mater. Chem. B, 2020, Accepted Manuscript , DOI: 10.1039/D0TB00149J

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