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Hyaluronic acid functionalized gold nanorods combined with copper-based therapeutic agents for chemo-photothermal cancer therapy

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Abstract

We herein report a hybrid nanocomposite (AuNRs-CTN@THA) which is based on hyaluronic acid-coated gold nanorods with loading of a copper complex through strong bonds. AuNRs-CTN@THA exhibits durable photothermal conversion capacity for pH-dominant and pH/temperature dual sensitive drug release, accomplishing synergetic antitumor efficacy and deep tumor penetration.

Graphical abstract: Hyaluronic acid functionalized gold nanorods combined with copper-based therapeutic agents for chemo-photothermal cancer therapy

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Article information


Submitted
12 Jan 2020
Accepted
12 Feb 2020
First published
18 Feb 2020

J. Mater. Chem. B, 2020, Advance Article
Article type
Communication

Hyaluronic acid functionalized gold nanorods combined with copper-based therapeutic agents for chemo-photothermal cancer therapy

L. Gao, L. Zhang, X. Zhu, J. Chen, M. Zhao, S. Li, C. Yu, L. Hu, H. Qiao and Z. Guo, J. Mater. Chem. B, 2020, Advance Article , DOI: 10.1039/D0TB00097C

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