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Fluorinated porphyrin-based theranostics for dual imaging and chemo-photodynamic therapy

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Abstract

Convenient strategies to transform regular liposomes or nano-micelles into multifunctional theranostics would be highly valuable in cancer therapy. Herein, we developed an amphiphilic fluorinated porphyrin dendrimer as a multifunctional “add-on” module which would self-assemble onto liposomal drug delivery systems and conveniently transform the liposomes into novel theranostics. Through cancer cells and murine xenograft tumor model assays, the theranostics showed valuable fluorescence/19F magnetic resonance dual modal imaging and highly efficient chemo-photodynamic therapy. The modular strategy facilitates the convenient and standardized preparation of multifunctional theranostics.

Graphical abstract: Fluorinated porphyrin-based theranostics for dual imaging and chemo-photodynamic therapy

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Supplementary files

Article information


Submitted
10 Jan 2020
Accepted
14 Apr 2020
First published
15 Apr 2020

J. Mater. Chem. B, 2020, Advance Article
Article type
Paper

Fluorinated porphyrin-based theranostics for dual imaging and chemo-photodynamic therapy

H. Zhang, S. Bo, K. Zeng, J. Wang, Y. Li, Z. Yang, X. Zhou, S. Chen and Z. Jiang, J. Mater. Chem. B, 2020, Advance Article , DOI: 10.1039/D0TB00083C

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