3D hollow-out TiO2 nanowire cluster / GOx as ultrasensitive photoelectrochemical glucose biosensor
Ultra-high sensitivity is difficult to achieve using conventional enzymatic glucose biosensors due to the lack of exposed active sites and steric-hinderance effect. Thus, in the present work, we report a photoelectrochemical (PEC) enzymatic glucose biosensor based on 3-dimensional (3D) hollow-out titanium dioxide (TiO2) nanowire clusters (NWc)/ glucose oxidase (GOx), with providing more exposed active sites, constructing a sensor with a higher affinity toward glucose reaction. Excellent performance with an ultra-high sensitivity of 58.9 μA mM−1 cm−2, 0-2 mM linear range with a limit of determination of 8.7 μM was obtained for the detection of glucose. This work might provide a new approach to expose active sites for remarkable photoelectrochemical performance efficiently.