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Issue 21, 2020
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Boron-based nanosheets for combined cancer photothermal and photodynamic therapy

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Abstract

Tumor phototherapy is of great significance for the expansion and advancement of cancer treatment methods. Herein, two-dimensional boron nanosheets (B NSs) with a thickness of 2.4 nm exhibiting an excellent photothermal conversion performance were developed via a simple liquid phase ultrasonic stripping method. Following the loading of the photosensitizer agent chlorin e6 (Ce6) and subsequent modification with poly(allylamine hydrochloride) (PAH) and poly(acrylic acid) (PAA), a B@Ce6–PAH–PAA NS nanomedicine exhibiting dual modal imaging-guided cancer photothermal therapy (PTT) and photodynamic therapy (PDT) properties, as well as outstanding stability was developed. The suitable nano-size (120 nm) of B@Ce6–PAH–PAA NSs can allow drugs to target tumor tissue with an enhanced permeability and retention effect (EPR). The cytotoxicity experiments demonstrated that B@Ce6–PAH–PAA NSs exhibited good biocompatibility even at high concentrations. Furthermore, the in vitro and in vivo experiments showed the excellent synergistic therapeutic effect of this nanomedicine for PTT and PDT.

Graphical abstract: Boron-based nanosheets for combined cancer photothermal and photodynamic therapy

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Supplementary files

Article information


Submitted
09 Jan 2020
Accepted
17 Apr 2020
First published
20 Apr 2020

J. Mater. Chem. B, 2020,8, 4609-4619
Article type
Paper

Boron-based nanosheets for combined cancer photothermal and photodynamic therapy

Y. Kang, X. Ji, Z. Li, Z. Su and S. Zhang, J. Mater. Chem. B, 2020, 8, 4609
DOI: 10.1039/D0TB00070A

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