Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.



Robust and nanostructured chitosan–silica hybrids for bone repair application

Author affiliations

Abstract

In this study, chitosan–silica hybrids (CSHs) with superior mechanical strength and homogeneous dispersion of nano-sized silica particles were synthesized via a facile sol–gel method aiming for bone regeneration. The effects of varied acidic conditions of sol–gel reaction and inorganic/organic ratios on the performance of the hybrid were investigated. CSHs synthesized under weak acidic conditions (acetic acid, pH 4.0) showed a homogeneous nanostructure and robust strength (maximum compressive strength: 42.6 ± 3.3 MPa and 271 ± 31 MPa in wet and dry forms, respectively). However, those developed under the strong acidic condition (HCl, pH 4.0) and the strong acid condition plus lower pH (HCl, pH 2.8) tended to aggregate and exhibited inferior mechanical properties (compressive strength: 6.3 ± 0.3 MPa in wet form at pH 2.8). Under the latter conditions, the interactions between silica and chitosan were weak. Moreover, the mechanical properties of the CSHs could be tuned in a wide range by conveniently varying the inorganic/organic composition ratio between 50% and 70%. In vitro cytocompatibility study indicated that CSHs were non-cytotoxic. These results suggested that the weak acidic sol–gel process were essential for fabricating chitosan–silica hybrids with high mechanical strength, which had potential to be applied as a bone substitute.

Graphical abstract: Robust and nanostructured chitosan–silica hybrids for bone repair application

Back to tab navigation

Article information


Submitted
02 Jan 2020
Accepted
02 Apr 2020
First published
10 Apr 2020

J. Mater. Chem. B, 2020, Advance Article
Article type
Paper

Robust and nanostructured chitosan–silica hybrids for bone repair application

J. Liang, L. Yan, Y. Dong, X. Liu, G. Wu and N. Zhao, J. Mater. Chem. B, 2020, Advance Article , DOI: 10.1039/D0TB00009D

Social activity

Search articles by author

Spotlight

Advertisements