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Issue 7, 2020
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A zipped-up tunable metal coordinated cationic polymer for nanomedicine

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Abstract

Incorporating metal elements into polymers is a feasible means to fabricate new materials with multiple functionalities. In this work, a metal coordinated cationic polymer (MCCP) was developed. Ferric ions were incorporated into the polyethyleneimine-β-cyclodextrin (PC) polymer chain via coordination to produce a zipped-up polymer with a micro-ordered and macro-disordered topological structure. By varying the metal concentration, a tunable superstructure could be formed on the nano-templates via the “zipping” effect. In addition, the physicochemical properties of the assembly of MCCPs and nucleic acids were tailored by tuning the composition of the metal ions and polymers. The loading efficiency of Rhodamine-B by MCCPs was enhanced. The in vitro and in vivo results showed that the hybrid materials could be adjusted to deliver nucleic acids or small molecules with good performance and acquired the capacity of generating reactive oxygen species in tumor cells. Thus, the tunable and multifunctional MCCP system has great potential in nanomedicine and biomaterial science.

Graphical abstract: A zipped-up tunable metal coordinated cationic polymer for nanomedicine

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Supplementary files

Article information


Submitted
31 Dec 2019
Accepted
30 Jan 2020
First published
30 Jan 2020

J. Mater. Chem. B, 2020,8, 1350-1358
Article type
Communication

A zipped-up tunable metal coordinated cationic polymer for nanomedicine

J. Mao, J. Wang, G. Tang, P. K. Chu and H. Bai, J. Mater. Chem. B, 2020, 8, 1350
DOI: 10.1039/C9TB02965F

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