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Issue 12, 2020
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Cell adhesion control by photoinduced LCST shift of PNIPAAm-based brush scaffolds

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Abstract

Poly(N-isopropylacrylamide) (PNIPAAm)-brush substrates are one of the most successful dynamic scaffolds for thermally controlling cell adhesion. Endowing substrates with photocontrollability promises further development and applications in the biomedical and bioengineering fields. In this study, we developed photoresponsive PNIPAAm copolymers by incorporation of spiropyran into the polymer chain, enabling the photoinduced shift of the lower critical solution temperatures. Their brush substrates were fabricated in a simple, facile grafting-to manner. Co-grafting with non-cell-adhesive poly(ethylene glycol) enhanced the modulation of surface chemical properties upon photostimulation; it enabled significant photocontrol of cell adhesion of several types with keeping culture temperature constant.

Graphical abstract: Cell adhesion control by photoinduced LCST shift of PNIPAAm-based brush scaffolds

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Supplementary files

Article information


Submitted
30 Dec 2019
Accepted
18 Feb 2020
First published
28 Feb 2020

J. Mater. Chem. B, 2020,8, 2393-2399
Article type
Paper

Cell adhesion control by photoinduced LCST shift of PNIPAAm-based brush scaffolds

K. Imato, K. Nagata, R. Watanabe and N. Takeda, J. Mater. Chem. B, 2020, 8, 2393
DOI: 10.1039/C9TB02958C

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