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Gold nanoparticle-conjugated nanomedicine: design, construction, and structure–efficacy relationship studies

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Abstract

In comparison with conventional therapies, nanomedicine shows prominent clinical performance, with better therapeutic efficacy and less off-target toxicity. As an important component of nanomedicine, gold nanoparticle (GNP)-based nanodrugs have attracted considerable interest because of their excellent performance given by the unique structure. Although no pharmaceutical formulations of GNP-associated nanodrugs have been officially marketed yet, a substantial amount of research on this aspect is being carried out, producing numerous GNP-based drug delivery systems with potential clinical applications. In this review, we present an overview of our progress on GNP-based nanodrugs combined with other achievements in biomedical applications, including drug-conjugated GNPs prepared for disease treatments and specific tumour targeting, structure–efficacy relationship (SER) studies on GNP-conjugated nanodrugs, and therapeutic hybrid nanosystems composed of GNPs. In addition, we also put forward some proposals to guide future work in developing GNP-based nanomedicine. We hope that this review will offer some useful experience for our peers and GNP-based nanodrugs will be utilized in the clinic with further persistent efforts.

Graphical abstract: Gold nanoparticle-conjugated nanomedicine: design, construction, and structure–efficacy relationship studies

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Article information


Submitted
24 Dec 2019
Accepted
27 Feb 2020
First published
02 Mar 2020

J. Mater. Chem. B, 2020, Advance Article
Article type
Review Article

Gold nanoparticle-conjugated nanomedicine: design, construction, and structure–efficacy relationship studies

W. Wang, J. Wang and Y. Ding, J. Mater. Chem. B, 2020, Advance Article , DOI: 10.1039/C9TB02924A

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