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Issue 17, 2020
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Recent advances of nanomedicines for liver cancer therapy

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Liver cancer is one of the most prevalent cancers and the third leading cause of cancer-related deaths worldwide. Liver cancer is insensitive to chemotherapeutic drugs due to its intrinsic or acquired drug resistance and the inability of delivering sufficient drugs to tumors via current chemotherapy. The emergence of nanomedicines offers a potential solution for this challenge. Nanomedicines utilize nanoscale or nanostructured materials in medicines for particular medical purposes. In this review, we illustrate the recent developments of various nanomedicines for liver cancer by presenting selected examples at different stages. Diverse nanomaterials, varied targeting moieties, and specific strategies for controlled release of nanomedicines for liver cancer therapy are summarized. Multifunctional nanomedicines for liver cancer are also discussed. This comprehensive review is aimed at providing quick access for readers to the cutting-edge nanomedicines in liver cancer therapy.

Graphical abstract: Recent advances of nanomedicines for liver cancer therapy

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Article information

18 Dec 2019
23 Feb 2020
First published
26 Feb 2020

J. Mater. Chem. B, 2020,8, 3747-3771
Article type
Review Article

Recent advances of nanomedicines for liver cancer therapy

X. Chi, K. Liu, X. Luo, Z. Yin, H. Lin and J. Gao, J. Mater. Chem. B, 2020, 8, 3747
DOI: 10.1039/C9TB02871D

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