Issue 17, 2020

Nanoclay-functionalized 3D nanofibrous scaffolds promote bone regeneration

Abstract

Developing a biomaterial that can promote osteoblastic differentiation, thereby reducing the needs of exogenous osteogenic factors for large bone repair, has been a significant and long-term technical hurdle. In this study, we developed an innovative nanoclay (nanosilicate, NS)-functionalized 3D gelatin nanofibrous scaffold (GF/NS) through a thermally induced phase separation method together with the particle leaching technique (TIPS&P). In addition to the significantly higher mechanical strength, the composite scaffolds (GF/NS) demonstrated a significantly stronger ability to promote the osteogenic differentiation of human mesenchymal stem cells (hMSCs) in vitro compared to the GF scaffold. Our data further revealed that this intriguing pro-osteoblastic functionality was largely because of the unique features of NS, particularly, the strong binding ability to pro-osteoblastic factors (e.g., BMP2) as well as the intrinsic osteoinductivity of its bioactive degradation products. Most importantly, our in vivo studies indicated that GF/NS scaffolds significantly improved low-dose BMP2-induced ectopic bone regeneration in mice.

Graphical abstract: Nanoclay-functionalized 3D nanofibrous scaffolds promote bone regeneration

Supplementary files

Article information

Article type
Paper
Submitted
12 Dec 2019
Accepted
02 Mar 2020
First published
02 Mar 2020

J. Mater. Chem. B, 2020,8, 3842-3851

Nanoclay-functionalized 3D nanofibrous scaffolds promote bone regeneration

Q. Yao, K. E. Fuglsby, X. Zheng and H. Sun, J. Mater. Chem. B, 2020, 8, 3842 DOI: 10.1039/C9TB02814E

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