Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 25, 2020
Previous Article Next Article

Adjustable and ultrafast light-cured hyaluronic acid hydrogel: promoting biocompatibility and cell growth

Author affiliations

Abstract

Bio-sourced hydrogels are attractive materials for diagnosing, repairing and improving the function of human tissues and organs. However, their mechanical strength decreases with an increase in water content. Furthermore, it is challenging to mold these hydrogels with high precision, which significantly limits their applications. Herein, we modified a biocompatible and biodegradable material, hyaluronic acid, with methacrylic anhydride and then cured it with a four-arm star structure cross-linking agent under ultraviolet light. The hyaluronic acid hydrogel was finally cured within 15 s with an adjustable cross-linking degree. The results demonstrated that the developed gel maintained good mechanical strength with a water content of 90%, while achieving micropatterns at a precision of 20 μm. The biological experiments showed that it could effectively promote the release of vascular endothelial growth factor (VEGF), which contributed to promoting cell growth, and has favorable biocompatibility. Overall, this hyaluronic acid hydrogel is a promising biomedical material with high forming accuracy, excellent mechanical properties, and favorable biocompatibility, which indicate its potential value in a variety of tissue engineering and biomedical applications.

Graphical abstract: Adjustable and ultrafast light-cured hyaluronic acid hydrogel: promoting biocompatibility and cell growth

Back to tab navigation

Supplementary files

Article information


Submitted
10 Dec 2019
Accepted
01 Jun 2020
First published
04 Jun 2020

J. Mater. Chem. B, 2020,8, 5441-5450
Article type
Paper

Adjustable and ultrafast light-cured hyaluronic acid hydrogel: promoting biocompatibility and cell growth

Q. Zhang, X. Wei, Y. Ji, L. Yin, Z. Dong, F. Chen, M. Zhong, J. Shen, Z. Liu and L. Chang, J. Mater. Chem. B, 2020, 8, 5441
DOI: 10.1039/C9TB02796C

Social activity

Search articles by author

Spotlight

Advertisements