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A Novel Elastic and Controlled-release poly(ether-ester-urethane)urea Scaffold for Cartilage Regeneration

Abstract

In the tissue engineering of cartilage, scaffolds with appropriate elasticity and controlled-release property are essential. Herein, we synthesized a poly(ether-ester-urethane)urea scaffold with pendant amino group (PEEUUN) through a de-protection process from PEEUU-Boc polymers and grafted kartogenin (KGN) onto the PEEUUN scaffolds (PEEUUN-KGN). Characterizations, performance test, biocompatibility of scaffolds and chondrogenesis both in vitro and in vivo were conducted. The results revealed the PEEUUN-KGN scaffolds were degradable and three-dimensional (3D) with interconnected pores, and possessed mechanical properties similar to those of native cartilage, as well as excellent cytocompatibility. Meanwhile, KGN on PEEUUN-KGN scaffolds underwent stable sustained release for a long time and promoted Human umbilical cord mesenchymal stem cells (HUCMSCs) to differentiate into chondrocytes in vitro, thus enhancing cartilage regeneration in vivo. In conclusion, the present PEEUUN-KGN scaffolds would have application potential for cartilage tissue engineering.

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Article information


Submitted
04 Dec 2019
Accepted
20 Mar 2020
First published
20 Mar 2020

J. Mater. Chem. B, 2020, Accepted Manuscript
Article type
Paper

A Novel Elastic and Controlled-release poly(ether-ester-urethane)urea Scaffold for Cartilage Regeneration

C. Chen, K. Huang, J. Zhu, Y. Bi, L. Wang, J. Jiang, T. Zhu, X. Yan and J. Zhao, J. Mater. Chem. B, 2020, Accepted Manuscript , DOI: 10.1039/C9TB02754H

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