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Heterodimers Made of Metal-Organic Frameworks and Upconversion Nanoparticles for Bioimaging and pH-responsive Dual-drug Delivery

Abstract

Developing multifunctional nanocomposite for pH-responsive controlled dual-drug delivery is still a huge challenge. Here we report a gentle and simple method to grow metal-organic frameworks (MOFs) that can load two anticancer drugs, DOX and 5-FU (Doxorubicin and 5-Fluorouracil), on the surface of upconversion nanoparticles (UCNPs) by reactions of Schiff base and electrostatic adsorption. The resulting pH-responsive UCMOFs@D@5 nanosystems show effective dual-drug release by cleavage of chemical bond and disruption of the MOFs structure under acidic conditions. Moreover, the final nanosystems UCMOFs@D@5 show much higher cytotoxicity in comparison with UCMOFs@D and UCMOFs@5 that loaded only one kind of drug, respectively, after being incubated with human cervical cancer (HeLa) cells, indicating that the Dox and 5-FU released from final nanosystems have synergistic effects on cytotoxicity. Cellular uptake studies show UCMOFs@D@5 can be well uptaken by HeLa cells and have potential bioimaging applications for intracellular fluorescence imaging with high-contrast, and beneficial for intracellular localization of anti-cancer drug. In addition, the nanosystems can be successfully applied for T1-weighted magnetic resonance imaging. Therefore, we developed a visualized tracking agent combined with MOFs to load two anticancer drugs to form the nanosystems for diagnosis and synergistic treatment, thus achieving the bioimaging and stimulation-responsive dual-drug release.

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Supplementary files

Article information


Submitted
04 Dec 2019
Accepted
30 Dec 2019
First published
03 Jan 2020

J. Mater. Chem. B, 2020, Accepted Manuscript
Article type
Paper

Heterodimers Made of Metal-Organic Frameworks and Upconversion Nanoparticles for Bioimaging and pH-responsive Dual-drug Delivery

D. Ling, H. Li, W. Xi, Z. Wang, A. Bednarkiewicz, S. T. Dibaba, L. Shi and L. Sun, J. Mater. Chem. B, 2020, Accepted Manuscript , DOI: 10.1039/C9TB02753J

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