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Substituted hydroxyapatite coatings of bone implants

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Abstract

Surface modification of orthopedic and dental implants has been demonstrated to be an effective strategy to accelerate bone healing at early implantation times. Among the different alternatives, coating implants with a layer of hydroxyapatite (HAp) is one of the most used techniques, due to its excellent biocompatibility and osteoconductive behavior. The composition and crystalline structure of HAp allow for numerous ionic substitutions that provide added value, such as antibiotic properties or osteoinduction. In this article, we will review and critically analyze the most important advances in the field of substituted hydroxyapatite coatings. In recent years substituted HAp coatings have been deposited not only on orthopedic prostheses and dental implants, but also on macroporous scaffolds, thus expanding their applications towards bone regeneration therapies. Besides, the capability of substituted HAps to immobilize proteins and growth factors by non-covalent interactions has opened new possibilities for preparing hybrid coatings that foster bone healing processes. Finally, the most important in vivo outcomes will be discussed to understand the prospects of substituted HAp coatings from a clinical point of view.

Graphical abstract: Substituted hydroxyapatite coatings of bone implants

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Article information


Submitted
29 Nov 2019
Accepted
05 Feb 2020
First published
05 Feb 2020

J. Mater. Chem. B, 2020, Advance Article
Article type
Review Article

Substituted hydroxyapatite coatings of bone implants

D. Arcos and M. Vallet-Regí, J. Mater. Chem. B, 2020, Advance Article , DOI: 10.1039/C9TB02710F

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