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Transition metal complexes as imaging or therapeutic agents for neurodegenerative diseases

Abstract

Neurodegenerative diseases are the result of neurodegeneration, which is the process of losing neuronal functions gradually due to the irreversible damage and death of neurons. Metal complexes have attracted intense interest over recent decades as probes or inhibitors of biomolecules. In this review, we discuss the application of transition metal complexes in the diagnosis and therapy of different neurodegenerative diseases. We first briefly introduce conventional approaches for the diagnosis and treatment of neurodegenerative diseases. Then, the characteristics and mechanisms of transition metal complexes as luminescent probes and drug candidates will be discussed. Representative examples of the use of metal complexes in targeted detection and treatment of neurodegenerative diseases will be highlighted. Finally, the challenges and future perspective of this field will be presented.

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Article information


Submitted
26 Nov 2019
Accepted
12 Feb 2020
First published
12 Feb 2020

J. Mater. Chem. B, 2020, Accepted Manuscript
Article type
Review Article

Transition metal complexes as imaging or therapeutic agents for neurodegenerative diseases

D. Ma, C. Wu, G. Li, T. Yung and C. Leung, J. Mater. Chem. B, 2020, Accepted Manuscript , DOI: 10.1039/C9TB02669J

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