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Layered Double Hydroxides Nanosheets: toward Ultrasensitive Tumor Microenvironment Responsive Synergetic Therapy

Abstract

Tumor microenvironment (TME), which is featured with a high H2O2 and glutathione (GSH) level, a low pH value and hypoxia, imposes crucial influences on tumor therapeutic outcomes. Rational design and preparation of nanomaterial systems that are responsive to the intrinsic properties of TME open a promising avenue toward tumor-specific treatment. Herein, CoMn-LDHs nanosheets were synthesized via a bottom-up method followed by a surface modification with a photosensitizer Chlorin e6 (Ce6), which exhibited TME-responsive imaging as well as photodynamic and chemodynamic synergetic therapy (PDT/CDT). Due to their ultralow bond energy and large adsorption energy, CoMn-LDHs nanosheets show fast self-degradability in GSH (10 mM) microenvironment, giving an excellent CDT activity in mild acidity (pH = 6.5), superior GSH removal ability (99.82%) as well as O2 production (35.37 μg L-1 s-1). Moreover, Ce6/CoMn-LDHs nanosheets display a satisfactory PA imaging and GSH-enhanced MR imaging with a 45.1-fold T1-enhancement. In addition, both in vitro and in vivo therapeutic tests based on Ce6/CoMn-LDHs demonstrate a satisfactory anticancer activity with a complete cancer cell apoptosis and dramatic tumor elimination. This work provides a new perspective for the design of multifunctional 2D nanosheets toward a fully promoted TME-responsive synergetic therapy, which holds great promises for future clinical diagnosis and treatment.

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Supplementary files

Article information


Submitted
18 Nov 2019
Accepted
08 Jan 2020
First published
09 Jan 2020

J. Mater. Chem. B, 2020, Accepted Manuscript
Article type
Paper

Layered Double Hydroxides Nanosheets: toward Ultrasensitive Tumor Microenvironment Responsive Synergetic Therapy

L. Yan, Y. Wang, T. Hu, X. Mei, X. Zhao, Y. Bian, L. Jin, R. Liang, X. Weng and M. Wei, J. Mater. Chem. B, 2020, Accepted Manuscript , DOI: 10.1039/C9TB02591J

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