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A Bi2S3@mSiO2@Ag nanocomposite for enhanced CT visualization and antibacterial response in the gastrointestinal tract

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Abstract

The non-invasive imaging of the gastrointestinal (GI) tract is highly desired for clinical research due to the various GI tract bacterial infection-induced diseases. To treat GI tract infections, various antibiotics have been used in the clinic. The growing problem of multidrug-resistant bacteria calls for effective antibiotic alternatives. Here, we construct a dual-functional Bi2S3@mSiO2@Ag nanocomposite for simultaneous enhanced X-ray computed tomography (CT) imaging and efficient antibacterial activity in the GI tract. The nanocomposite also has good stability, low cytotoxicity, and negligible hemolysis. Moreover, the investigation of the long-term toxicity and biodistribution of the Bi2S3@mSiO2@Ag nanocomposite after oral administration confirms its safety at the tested dosage. In particular, Ag nanoparticles (NPs) well dispersed on a silica substrate can reduce the antibacterial dosage and enhance the antibacterial activity of the Bi2S3@mSiO2@Ag nanocomposite. Furthermore, we have established bacterially infected enteritis animal models to confirm the antibacterial ability of the nanocomposite. This work opens up a new avenue for the design of a nanotheranostic agent that acts as both a contrast agent for the enhanced visualization of the GI tract and an antibacterial agent as an alternative to antibiotics.

Graphical abstract: A Bi2S3@mSiO2@Ag nanocomposite for enhanced CT visualization and antibacterial response in the gastrointestinal tract

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Supplementary files

Article information


Submitted
13 Nov 2019
Accepted
13 Dec 2019
First published
17 Dec 2019

J. Mater. Chem. B, 2020, Advance Article
Article type
Paper

A Bi2S3@mSiO2@Ag nanocomposite for enhanced CT visualization and antibacterial response in the gastrointestinal tract

Y. Zu, L. Yan, T. Wang, D. Ma, X. Dong, Z. Du and W. Yin, J. Mater. Chem. B, 2020, Advance Article , DOI: 10.1039/C9TB02562F

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