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Recent Advances in Heparinization of Polymeric Membranes for Enhanced Continuous Blood Purification

Abstract

Continuous blood purification technology such as hemodiafiltration has been used worldwide for saving patients suffering from severe diseases or organ function failure, especially in the intensive care unit and emergency setting. The filters as core devices are commonly made of polymer materials as hollow fiber membranes. However, the membrane is often inductively blocked by blood clotting formation due to its interactions with blood components. Heparin is the anticoagulant often used in clinical practice for anti-coagulation. Recently, heparin is also employed to modify the hollow fiber membranes either chemically or physically to improve the filtration performance. This review summarizes recent advances in methodology about surface heparinization of such hollow fiber membranes, and their filtration performance improvement. The review also provides the expert opinions for the further research in this rapid expanding field.

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Article information


Submitted
08 Nov 2019
Accepted
28 Dec 2019
First published
30 Dec 2019

J. Mater. Chem. B, 2020, Accepted Manuscript
Article type
Review Article

Recent Advances in Heparinization of Polymeric Membranes for Enhanced Continuous Blood Purification

L. Shan, Y. Sun, F. Shan, L. Li and Z. P. Xu, J. Mater. Chem. B, 2020, Accepted Manuscript , DOI: 10.1039/C9TB02515D

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