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A ratiometric fluorescent probe for detecting the endogenous biological signaling molecule superoxide anion and bioimaging during tumor treatment

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Abstract

Tumor resistance and drug-induced nephrotoxicity pose great challenges to the clinical treatment of tumors, and they also limit the clinical application of oncology drugs. Finding an effective adjuvant, which can sensitize tumor treatment, is an effective method for tumor treatment. Here, we developed a ratiometric fluorescent probe, TP-Tfs, for superoxide anion (O2˙) detection in living cells and in vivo during the process of tumor treatment for the first time. TP-Tfs with simple synthesis steps and high yields can detect O2˙ sensitively and selectively, and the detection limit was determined to be 37 nM. Using TP-Tfs, we found that cis-diaminodichloroplatinum(II) (DDP) was effective in treating tumors by inducing O2˙ burst. Curcumin (cum) can sensitize tumor treatment effectively by inducing more severe O2˙ burst. These results indicated that the probe TP-Tfs was a promising candidate for drug screening and tumor treatment evaluation.

Graphical abstract: A ratiometric fluorescent probe for detecting the endogenous biological signaling molecule superoxide anion and bioimaging during tumor treatment

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Supplementary files

Article information


Submitted
03 Nov 2019
Accepted
30 Dec 2019
First published
02 Jan 2020

J. Mater. Chem. B, 2020, Advance Article
Article type
Paper

A ratiometric fluorescent probe for detecting the endogenous biological signaling molecule superoxide anion and bioimaging during tumor treatment

Y. Wang, X. Wang, L. Zhang, Y. Huang, L. Bi, C. Lv and L. Chen, J. Mater. Chem. B, 2020, Advance Article , DOI: 10.1039/C9TB02453K

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