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Controlled polymerization for the development of bioconjugate polymers and materials

Abstract

Controlled polymerization through living radical polymerization is widely studied. Controlled polymerization enables synthetic polymers to have a precise structure with a similar aspect. Synthetic polymers with a precise structure have the potential to be excellent bio-functional materials. This review summarizes the applications of controlled polymers, especially living radical polymerization, to biomaterials and their fusion with biomolecules. In the case of polymer ligands like glycopolymers, there have been reports of molecules that control the interactions with proteins and cells based on the precise polymer structures. Living radical polymerization enables the conjugation of polymers to proteins, antibodies and cells. Those polymer conjugations are sophisticated method to modify the bio-organisms. The polymer conjugations expand the potential of biomaterials and are useful for understanding biology.

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Article information


Submitted
30 Oct 2019
Accepted
31 Jan 2020
First published
03 Feb 2020

J. Mater. Chem. B, 2020, Accepted Manuscript
Article type
Review Article

Controlled polymerization for the development of bioconjugate polymers and materials

Y. Miura, J. Mater. Chem. B, 2020, Accepted Manuscript , DOI: 10.1039/C9TB02418B

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