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Facile synthesis of polypyrrole–rhodamine B nanoparticles for self-monitored photothermal therapy of cancer cells

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Abstract

Photothermal therapy following microscopic temperature detection can avoid overheating effects or insufficient heating, and thus improve therapeutic efficacy. In this study, biocompatible dual-functional nanoparticles (NPs) are constructed from polypyrrole (PPy) and rhodamine B (RB) by a one-step modified polymerization method. The polypyrrole serves as a photothemal agent, and rhodamine B acts as a temperature-sensing probe. The polypyrrole–rhodamine B (PPy–RB) NPs possess a high photothermal effect on irradiation by 808 nm laser, and a competent temperature sensitivity for the real-time temperature monitoring based on the emission intensity response of rhodamine B. After acting on HepG2 cells, the PPy–RB NPs can effectively induce cancer cell death, and the microscopic temperature is monitored by fluorescence feedback from rhodamine B during PTT by laser confocal microscopy. Hence, the proposed approach can supply a facile and promising way for the fabrication of effective theranostic nanoplatforms assisted by self-monitoring of cancer therapeutic processes.

Graphical abstract: Facile synthesis of polypyrrole–rhodamine B nanoparticles for self-monitored photothermal therapy of cancer cells

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Supplementary files

Article information


Submitted
14 Oct 2019
Accepted
18 Dec 2019
First published
20 Dec 2019

J. Mater. Chem. B, 2020, Advance Article
Article type
Paper

Facile synthesis of polypyrrole–rhodamine B nanoparticles for self-monitored photothermal therapy of cancer cells

X. Wang, X. Chen, H. Peng, X. Wei, X. Wang, K. Cheng, Y. Liu and W. Yang, J. Mater. Chem. B, 2020, Advance Article , DOI: 10.1039/C9TB02274K

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