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A unique polarity-sensitive photothermal sensitizer revealing down-regulated mitochondrial polarity during photo-induced cell death

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Abstract

Photothermal therapy (PTT) is a highly selective and non-invasive method to remove tumor tissues, and a promising potential method to combat cancer in the near future. However, the physical changes inside cells during photo-induced cell death have not been studied yet, due to the lack of proper tools. In this work, a polarity-sensitive PTT sensitizer was fabricated for the first time, to investigate the intracellular polarity change during photo-induced cell death. The probe targets mitochondria in live cells and can detect the polarity change induced by the addition of cholesterol in a ratiometric manner. The cell viability of live Hepg2 cells pre-incubated with the probe could be dramatically decreased after laser irradiation within 5 min. The down-regulated mitochondrial polarity during photo-induced cell death was successfully revealed by using the probe.

Graphical abstract: A unique polarity-sensitive photothermal sensitizer revealing down-regulated mitochondrial polarity during photo-induced cell death

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Article information


Submitted
11 Oct 2019
Accepted
09 Dec 2019
First published
11 Dec 2019

J. Mater. Chem. B, 2020, Advance Article
Article type
Paper

A unique polarity-sensitive photothermal sensitizer revealing down-regulated mitochondrial polarity during photo-induced cell death

C. Liu, M. Tian and W. Lin, J. Mater. Chem. B, 2020, Advance Article , DOI: 10.1039/C9TB02233C

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