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An Au@NH2-MIL-125(Ti)-based multifunctional platform for colorimetric detections of biomolecules and Hg2+

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Abstract

In this report, a novel nanocomposite of highly dispersed Au nanoparticles deposited on NH2-MIL-125(Ti) was designed and proposed as a peroxidase-like mimic. Compared with individual Au nanoparticles and NH2-MIL-125(Ti), the peroxidase-like nanozyme exhibits enhanced peroxidase-like activity. Moreover, kinetic analysis reveals that the as-prepared nanozyme has lower Km values and stronger affinity towards both substrates than the natural horseradish peroxidase (HRP). The detection limits of the multifunctional platform for H2O2, cysteine and Hg2+ are down to 0.24 μM, 0.14 μM and 100 nM, respectively. This work provides rapid and sensitive colorimetric detection strategies for small biomolecules and Hg2+, which have great potential for application in biosensors and biotechnology.

Graphical abstract: An Au@NH2-MIL-125(Ti)-based multifunctional platform for colorimetric detections of biomolecules and Hg2+

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Publication details

The article was received on 05 Oct 2019, accepted on 08 Nov 2019 and first published on 28 Nov 2019


Article type: Paper
DOI: 10.1039/C9TB02183C
J. Mater. Chem. B, 2020, Advance Article

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    An Au@NH2-MIL-125(Ti)-based multifunctional platform for colorimetric detections of biomolecules and Hg2+

    Y. Zhang, J. Song, Q. Pan, X. Zhang, W. Shao, X. Zhang, C. Quan and J. Li, J. Mater. Chem. B, 2020, Advance Article , DOI: 10.1039/C9TB02183C

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